131 Epidermal autophagy and nucleophagy

Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration

The terminal stages of neuronal degeneration and death in neurodegenerative diseases remain elusive. Autophagy is an essential catabolic process frequently failing in neurodegeneration. Selective autophagy routes have recently emerged, including nucleophagy, defined as degradation of nuclear components by autophagy. Here, we show that, in a mouse model for the polyglutamine disease dentatorubra...

A Late Form of Nucleophagy in Saccharomyces cerevisiae

Autophagy encompasses several processes by which cytosol and organelles can be delivered to the vacuole/lysosome for breakdown and recycling. We sought to investigate autophagy of the nucleus (nucleophagy) in the yeast Saccharomyces cerevisiae by employing genetically encoded fluorescent reporters. The use of such a nuclear reporter, n-Rosella, proved the basis of robust assays based on either ...

131 - Hypothermia and Frostbite

Accidental hypothermia is generally manifested as progression from an initial state of catecholamine release and stimulation (mild hypothermia) to one marked by a predictable slowing of metabolism and all critical body functions to the extent that patients may appear dead. The profound physiologic changes and metabolic slowing all reverse with rapid rewarming, and reports of remarkable neurolog...

Colocalization of Vitiligo and Verrucous Epidermal Nevus: A Simulator of Depigmented Variant of Verrucous Epidermal Nevus

Vitiligo, an autoimmune disorder, is known to co-localize with other immunological disorders like lichen planus and psoriasis. However, there are no reports regarding the co-localization of an autoimmune disorder (vitiligo) and a developmental disorder (verrucous epidermal nevus). We hereby present a 10-month-old infant who was visited for white patches on the right buttock and adjoining antero...

Iodine-131 and Thyroid Function